The Drug-Induced Respiratory Disease Website

Ibrutinib

Heart failure (biventricular, congestive)

Can occur as a consequence of several pulmonary obliterative vasculopathies. Cardiac tamponade may mimic this condition. See under VI

Zhu J, Bian SY

Late-chronic cardiotoxicity and heart failure caused by ibrutinib: a case report and literature review.

Journal of geriatric cardiology : JGC 2021 Apr 28;18;307-311 — 2021 Apr 28 — 307-311

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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