The Drug-Induced Respiratory Disease Website

Coronary artery disease (acute) - Myocardial ischemia/infarction

Including acute coronary artery disease or spasm and acute ST segment elevation on ECG/EKG. See also under Xg, XIIo and XIIaf

Parkin L, Williams S, Sharples K, Barson D, Horsburgh S, Jackson R, Wu B, Dummer J

Dual versus single long-acting bronchodilator use could raise acute coronary syndrome risk by over 50%: A population-based nested case-control study.

Journal of internal medicine 2021 11;290;1028-1038 — 2021 11 — 1028-1038

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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