The Drug-Induced Respiratory Disease Website

Ranolazine

Generalized myopathy/muscle weakness

Or paralysis

Paul P, Vazquez Do Campo R, Liewluck T, Naddaf E

Ranolazine-induced lipid storage myopathy presenting with respiratory failure and head drop.

Neuromuscular disorders : NMD 2021 06;31;546-550 — 2021 06 — 546-550

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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