The Drug-Induced Respiratory Disease Website

Amiodarone

Unilateral interstitial lung disease

Chen J, Hinton S

Acute amiodarone interstitial toxicity presenting as unilateral pneumonitis.

BMJ case reports 2021 Dec 31;14; — 2021 Dec 31

Camus P, Lombard JN, Perrichon M, Piard F, Guérin JC, Thivolet FB, Jeannin L

Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.

Thorax 1989 Sep;44;711-5 — 1989 Sep — 711-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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