The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Barrio Piqueras M, Ezponda A, Felgueroso C, Urtasun C, Di Frisco IM, Larrache JC, Bastarrika G, Alcaide AB
Acute Eosinophilic Pneumonia Following mRNA COVID-19 Vaccination: A Case Report.
Archivos de bronconeumologia 2021 Nov 16;; — 2021 Nov 16
Eosinophilic pneumonia and COVID-19 vaccination.
QJM : monthly journal of the Association of Physicians 2022 Feb 15;; — 2022 Feb 15
Acute Eosinophilic Pneumonia Associated With the Anti-COVID-19 Vaccine AZD1222.
Cureus 2021 Oct;13;e18959 — 2021 Oct — e18959