The Drug-Induced Respiratory Disease Website

CAR T-cell therapy

Heart failure (biventricular, congestive)

Can occur as a consequence of several pulmonary obliterative vasculopathies. Cardiac tamponade may mimic this condition. See under VI

Burns EA, Gentille C, Trachtenberg B, Pingali SR, Anand K

Cardiotoxicity Associated with Anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Recognition, Risk Factors, and Management.

Diseases (Basel, Switzerland) 2021 Mar 17;9; — 2021 Mar 17

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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