The Drug-Induced Respiratory Disease Website

CAR T-cell therapy

Pulmonary infiltrates

Sometimes not specified otherwise

Sun Z, Xie C, Liu H, Yuan X

CD19 CAR-T Cell Therapy Induced Immunotherapy Associated Interstitial Pneumonitis: A Case Report.

Frontiers in immunology 2022;13;778192 — 2022 — 778192

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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