The Drug-Induced Respiratory Disease Website

Cisplatin

Bradycardia

Bin Naeem S, Azhar M, Baloch NU, Abbas M, Waheed M, Masood Sheikh R

Cisplatin-Induced Bradycardia: A Silent Risk Observed in Two Different Clinical Cases.

Cureus 2021 Nov;13;e19769 — 2021 Nov — e19769

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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