The Drug-Induced Respiratory Disease Website

CAR T-cell therapy

Interstitial pulmonary edema

de Groot PM, Arevalo O, Shah K, Strange CD, Shroff GS, Ahuja J, Truong MT, de Groot JF, Vlahos I

Imaging Primer on Chimeric Antigen Receptor T-Cell Therapy for Radiologists.

Radiographics : a review publication of the Radiological Society of North America, Inc 2022 Jan-Feb;42;176-194 — 2022 Jan-Feb — 176-194

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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