The Drug-Induced Respiratory Disease Website

BCG therapy (topical instillations in the urinary bladder)

Imaging: A 'tree-in-bud' pattern

See PMID 22343402 & 23948769. Careful consideration of diffuse aspiration bronchiolitis is indicated (PMID 25972969)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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