The Drug-Induced Respiratory Disease Website

Brodifacoum, inhaled

Coagulopathy

May stem from thrombocytopenia or pancytopenia, DIC, drug-drug interaction with an vitamin K antagonist, or direct vitamin K antagonism. May lead to any pattern of bleeding under pattern family II

Publications

Wright E, Hafner JW, Podolej G, Feinstein DL, van Breemen R, Rubinstein I, Aks S, Wahl M

Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations.

The western journal of emergency medicine 2021 Jul 15;22;1014-1019 — 2021 Jul 15 — 1014-1019

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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