The Drug-Induced Respiratory Disease Website

Amiodarone

Imaging: Waxing and waning nodules

Griffith C, Hossain S, Minupuri A, Korman M

Nodules that Wax and Wane: Unusual Presentation of Amiodarone Lung Toxicity.

Cureus 2020 Jul 08;12;e9058 — 2020 Jul 08 — e9058

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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