The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Unilateral/Hemilingual (angio)edema

Gil Braga B, Cravo M, Neves P, Pinto F, Mendonça C

A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors.

Acta medica portuguesa 2022 May 25;; — 2022 May 25

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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