The Drug-Induced Respiratory Disease Website
(Fr: PnP avec granulomes). 2018 review at PMID 29698718. Characteristically nonnecrotizing, noninfectious, sterile granulomas. Although this is a pathologic pattern, the condition is suspected on a miliary appearance on imaging. Hilar/mediastinal lymphadenopathy can be present. May mimic pulmonary and/or systemic sarcoidosis. Concomittant skin lesions may show granulomas. A confirmarptory lung biopsy may be required (See under Pathology XIV). Careful exclusion of mycobacterial, fungal and Pneumocystis infection is crucial (See PMID 10678649, 18054121, 17257125).
Publications
Tronconi MC, Marinello A, Solferino A, Grimaudo S, Ciccarelli M, Manara S, Cozzaglio L, Mancini L, Borroni R, Santoro A
A Case of Pulmonary Sarcoidosis during First-Line Targeted Therapy with Dabrafenib Plus Trametinib in V600E-Mutated Metastatic Melanoma.
Case reports in oncology 2022 May-Aug;15;560-565 — 2022 May-Aug — 560-565