The Drug-Induced Respiratory Disease Website

Dabrafenib-Trametinib combination (BRAFi)

Granulomatous mediastinal lymphadenopathy

Tronconi MC, Marinello A, Solferino A, Grimaudo S, Ciccarelli M, Manara S, Cozzaglio L, Mancini L, Borroni R, Santoro A

A Case of Pulmonary Sarcoidosis during First-Line Targeted Therapy with Dabrafenib Plus Trametinib in V600E-Mutated Metastatic Melanoma.

Case reports in oncology 2022 May-Aug;15;560-565 — 2022 May-Aug — 560-565

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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