The Drug-Induced Respiratory Disease Website

Flecainide

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Chauhan S, Morris D, Bhatnagar M, Shah P, Narula DD

A Rare Case Report of Flecainide-Induced Left Bundle Branch Block (LBBB) and Transient Cardiomyopathy.

Cureus 2023 Apr;15;e37184 — 2023 Apr — e37184

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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