The Drug-Induced Respiratory Disease Website

Polyethylene glycol (PEG)

Pulmonary infiltrates

Sometimes not specified otherwise

Murphy RJ, Tessier S, Longo S, Alia CS, Ido F

Extrinsic lipoid pneumonia due to chronic polyethylene glycol consumption: A case report.

Respiratory investigation 2023 Nov;61;768-772 — 2023 Nov — 768-772

Brancaleone P, Delefortrie Q, Descamps O, Weynand B, Vanbever R, Detry G

Lipoid Pneumonia Associated with Polyethylene Glycol Chronic Aspiration.

American journal of respiratory and critical care medicine 2023 Apr 15;207;e71-e72 — 2023 Apr 15 — e71-e72

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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