The Drug-Induced Respiratory Disease Website

Hydroxychloroquine

Path: Lysosomal storage cardiomyopathy/cardiotoxicity

Malhotra A, Pathak MA, Dalia T, Vidic A

Endomyocardial biopsy-proven hydroxychloroquine-induced cardiomyopathy in a patient with rheumatoid arthritis.

BMJ case reports 2023 Apr 13;16; — 2023 Apr 13

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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