The Drug-Induced Respiratory Disease Website

Amiodarone

Respiratory failure (hypoxemia, acidosis) from myxedema coma

Alnaeem MM, Suleiman KH, Mansour NH, Alwahsh BS, Nashwan AJ

Amiodarone-Induced Myxedema Coma in Elderly Patients: A Systematic Review of Case Reports.

Cureus 2023 Jun;15;e40893 — 2023 Jun — e40893

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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