The Drug-Induced Respiratory Disease Website

Atezolizumab

Antisynthetase antibodies (ASA) - ASA syndrome

Including flare of preexisting ASA syndrome

Miyamoto I, Shimizu T, Kusahana R, Nomoto M, Fujiwara D, Nishizawa T, Hayashi K, Nakagawa Y, Gon Y

Anti-synthetase syndrome-associated interstitial lung disease possibly caused by atezolizumab in a patient with lung adenocarcinoma: a case report.

BMC pulmonary medicine 2023 May 08;23;159 — 2023 May 08 — 159

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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