The Drug-Induced Respiratory Disease Website

Tricyclic antidepressants - Tricyclic antidepressant poisoning

Cardiovascular collapse - Cardiogenic shock - Hypotension

See also under Xf and XIIe, , f, g, k, l, o, s, t, ad, ag

Zitoune Z, Kugener L, Jonckheer J, Lanckmans K, Hantson P, Devriendt J, Honore PM

Effective Treatment of Acute Tricyclic Antidepressant Poisoning with Cardiogenic Shock and Severe Rhabdomyolysis Using ECMO and CytoSorb® Adsorber.

The American journal of case reports 2023 Aug 05;24;e939884 — 2023 Aug 05 — e939884

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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