The Drug-Induced Respiratory Disease Website

Penpulimab

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Shen L, Xu L, Wang Y, Wu Y, Duan X

Penpulimab-induced complete atrioventricular block in a patient with metastatic renal cancer.

HeartRhythm case reports 2023 Jul;9;451-455 — 2023 Jul — 451-455

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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