The Drug-Induced Respiratory Disease Website

Nitrofurantoin

A restrictive lung function defect

Capaccione KM, Tran CV, Leb JS, Salvatore MM, D'souza B

Acute pulmonary function decline and radiographic abnormalities: chronic cause?

Breathe (Sheffield, England) 2021 Mar;17;200286 — 2021 Mar — 200286

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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