The Drug-Induced Respiratory Disease Website

Imatinib

Chylous pericardial effusion (w/wo tamponade)

Donovan DJ, Siskind T, Thanjan MT, Holzer RJ, Dayton JD, Carroll SJ

Chylous pericardial effusion with cardiac tamponade in a child treated with imatinib.

Cardiology in the young 2023 Jul;33;1217-1219 — 2023 Jul — 1217-1219

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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