The Drug-Induced Respiratory Disease Website

Sirolimus

Airway hyperresponsiveness

(Fr: hyperréactivité bronchique)

Steagall WK, Stylianou M, Pacheco-Rodriguez G, Yu ZX, Moss J

Unexpected sirolimus-stimulated airway hyperreactivity in lymphangioleiomyomatosis.

ERJ open research 2023 Jul;9; — 2023 Jul

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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