The Drug-Induced Respiratory Disease Website

Lamotrigine

Eosinophilic myocarditis

Publications

Doan KD, Akinsanya A, Kuhar M, Mesa H

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2023 Oct 25;19;92 — 2023 Oct 25 — 92

Kowtoniuk R, Pinninti M, Tyler W, Doddamani S

DRESS syndrome-associated acute necrotizing eosinophilic myocarditis with giant cells.

BMJ case reports 2018 Oct 08;2018; — 2018 Oct 08

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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