The Drug-Induced Respiratory Disease Website

Amiodarone

Chronic pneumonitis/ILD

Often requires prolonged corticosteroid therapy and/or immunosuppression

Budin CE, Cocuz IG, Sab?u AH, Niculescu R, Ianosi IR, Ioan V, Cotoi OS

Pulmonary Fibrosis Related to Amiodarone-Is It a Standard Pathophysiological Pattern? A Case-Based Literature Review.

Diagnostics (Basel, Switzerland) 2022 Dec 19;12; — 2022 Dec 19

Suárez LD, Poderoso JJ, Elsner B, Bunster AM, Esteva H, Bellotti M

Subacute pneumopathy during amiodarone therapy.

Chest 1983 Mar;83;566-8 — 1983 Mar — 566-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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