The Drug-Induced Respiratory Disease Website

Oxymetazoline

Flash (fulminate) pulmonary edema

(Fr: OAP flash ou subit. Peut apparaitre en qq minutes). Flash PE typicall develops within minutes of exposure to the drug, sometimes after first tablet ever

Publications

Godbe KN, Sinik LM, Lemons DV, Sokol JA

Nose-Ocomial Pulmonary Edema: A Rare Complication of Oxymetazoline.

Ophthalmic plastic and reconstructive surgery 2023 Sep 18;; — 2023 Sep 18

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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