The Drug-Induced Respiratory Disease Website

Fluoroquinolones

Veterinary: Flare of Myasthenia gravis

Guzman KMH, Harkin K

Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.

Journal of the American Animal Hospital Association 2023 Sep 01;59;249-254 — 2023 Sep 01 — 249-254

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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