The Drug-Induced Respiratory Disease Website

Denosumab

Pulmonary infiltrates

Sometimes not specified otherwise

Ouakidi D, Bourouis BN, Banat MA, Azzi N, Benzait S, Snouber A

Secondary Organising Pneumonia Caused by Denosumab.

European journal of case reports in internal medicine 2023;10;004043 — 2023 — 004043

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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