The Drug-Induced Respiratory Disease Website

BRAF/METi combination therapy

Granulomatous mediastinal lymphadenopathy

Gouveris P, Zouki DN, Sarris EG, Kolilekas L, Tryfonopoulos D, Papaxoinis G, Demiri S

Melanoma and Sarcoidosis in Patients Receiving or Not Antineoplastic Therapy.

Case reports in oncology 2021;14;1059-1065 — 2021 — 1059-1065

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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