The Drug-Induced Respiratory Disease Website

Methylene blue

Bluish, blue, pseudocyanotic skin discoloration

Bluish skin discoloration. See also under XIa, XIVa, XIVb.

Blass N, Fung D

Dyed but not dead--methylene blue overdose.

Anesthesiology 1976 Oct;45;458-9 — 1976 Oct — 458-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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