The Drug-Induced Respiratory Disease Website

Fluorouracil (5-FU)

Halitosis - Breath malodor

See review at PMID 29164566

Scott A, Rao SV, Affronti ML

Hyperammonemia Secondary to 5-Fluorouracil.

Journal of the advanced practitioner in oncology 2023 Jul;14;414-418 — 2023 Jul — 414-418

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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