The Drug-Induced Respiratory Disease Website

Nivolumab

Bronchiolitis (a clinical-imaging pattern suggestive of)

Including a tree-in-bud appearance on HRCT

Basir S, Bosiers J, Westgeest HM, Yick DCY, van Werven JR, van der Leest CH

Bronchiolitis after Combination Immunotherapy With Ipilimumab and Nivolumab in a Melanoma Patient.

Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Feb 27;; — 2024 Feb 27

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.