The Drug-Induced Respiratory Disease Website

Bicalutamide

Heart failure (biventricular, congestive)

Can occur as a consequence of several pulmonary obliterative vasculopathies. Cardiac tamponade may mimic this condition. See under VI

Abdulfattah AY, Tajuddin S, Akkari N, Elsayed OI, Graham-Hill S

A Rare Case of Bicalutamide-Induced Severe Congestive Heart Failure in a Patient With Advanced Prostate Cancer.

Cureus 2024 May;16;e60298 — 2024 May — e60298

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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