The Drug-Induced Respiratory Disease Website

Flecainide

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

See: Zellweger JP, Streiss S. Swiss Medical Preprint 2024 https:/:doi.org/10.57187/preprint.8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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