The Drug-Induced Respiratory Disease Website

FOLFOX chemotherapy regimen

Fatal pulmonary fibrosis

Urlapu KS, Lvovsky D

Oxaliplatin-Induced Pulmonary Fibrosis: A Rare but Fatal Reality.

Cureus 2023 Dec;15;e51411 — 2023 Dec — e51411

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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