The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Fatal intoxication with new synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA.
Clinical toxicology (Philadelphia, Pa.) 2019 Feb 26;;1-6 — 2019 Feb 26 — 1-6
Clinical images in medical toxicology: heroin overdose with non-cardiogenic pulmonary edema.
Clinical toxicology (Philadelphia, Pa.) 2006;44;399 — 2006 — 399
Thoracic complications of illicit drug use: an organ system approach.
Radiographics : a review publication of the Radiological Society of North America, Inc 2002 Oct;22 Spec No;S119-35 — 2002 Oct — S119-35
Non-cardiogenic pulmonary edema after narcotic treatment for cancer pain.
Pain 1989 Dec;39;297-300 — 1989 Dec — 297-300
Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia.
Anesthesiology 1977 Oct;47;376-8 — 1977 Oct — 376-8