The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
A case report on acute pulmonary edema induced by adverse drug event immediately after cesarean section.
International journal of surgery case reports 2025 Jan 29;128;110991 — 2025 Jan 29 — 110991
Oxytocin-Induced Acute Pulmonary Edema: A Case Report and Literature Review.
Cureus 2021 May 16;13;e15067 — 2021 May 16 — e15067
Fatal pulmonary oedema following oxytocin administration in a pregnant woman with acute myocardial infarction.
Cardiovascular toxicology 2011 Mar;11;74-7 — 2011 Mar — 74-7
Acute pulmonary oedema following oxytocin administration: a life threatening complication.
Journal of the Indian Medical Association 2006 May;104;261-2 — 2006 May — 261-2
Pulmonary edema during cesarean section related to the use of oxytocic drugs.
Acta anaesthesiologica Belgica 1984 Jun;35;155-64 — 1984 Jun — 155-64
The cardiovascular effects of oxytocic drugs.
British journal of anaesthesia 1972 Aug;44;826-34 — 1972 Aug — 826-34
Pulmonary edema possibly developing secondary to the intravenous administration of oxytocin.
Veterinary and human toxicology 1991 Dec;33;587-8 — 1991 Dec — 587-8