The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
A new side effect of synthetic cannabinoid use by the bucket (waterpipe) method: Acute respiratory distress syndrome (ARDS).
Turkish journal of emergency medicine 2018 Mar;18;42-44 — 2018 Mar — 42-44
New "lethal highs": a case of a deadly cocktail of GHB and Mephedrone.
Forensic science international 2012 Nov 30;223;e38-41 — 2012 Nov 30 — e38-41
Association of pulmonary histopathological findings with toxicological findings in forensic autopsies of illicit drug users.
Vojnosanitetski pregled 2011 Aug;68;639-42 — 2011 Aug — 639-42
Acute respiratory failure from abused substances.
Journal of intensive care medicine 2004 Jul-Aug;19;183-93 — 2004 Jul-Aug — 183-93
Methamphetamine and the expanding complications of amphetamines.
The Western journal of medicine 1999 Apr;170;214-9 — 1999 Apr — 214-9