The Drug-Induced Respiratory Disease Website
(Fr: SDRA sur critères gazométriques PaO2/FIO2). May overlap with Ia. Mechanical ventilation commonly needed. ECMO required in some instances (PMID 29967877). ARDS definition and grading at PMID 22797452. ARDS (and formerly ALI) are defined on the basis of gas exchange abnormalities. Thus, ARDS is not a well-characterized disease entity and may arise in widely disparate clinical scenarios. Pathologically, ARDS may correspond to DAD, pulmonary edema, acute NSIP-like ILD w/wo granulomas, -eosinophilic pneumonia (AEP), AFOP, amiodarone pulmonary toxicity, DAH, fat or silicone embolism, AIP, radiation injury, pulmonary fibrosis exacerbated by drugs or surgery (see under specific patterns) and drug- or alcohol-induced aspiration pneumonitis (see under XIg). Appropriate tests and BAL help exclude an infection and separate these entities. Some patients respond to intravenous corticosteroid therapy. Review at PMID 1939859. See also under IL 'Diffuse Alveolar Damage', XIg, XVf and under 'Postoperative ARDS'
Publications
Prognostic factors in acute methadone toxicity: a 5-year study.
Journal of toxicology 2014;2014;341826 — 2014 — 341826
Acute respiratory distress syndrome caused by methadone syrup.
Arhiv za higijenu rada i toksikologiju 2013 Sep;64;439-43 — 2013 Sep — 439-43
[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].
Presse medicale (Paris, France : 1983) 2011 Apr;40;436-8 — 2011 Apr — 436-8
Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation.
Emergency medicine journal : EMJ 2007 Sep;24;681 — 2007 Sep — 681
Pulmonary edema and adult respiratory distress syndrome following methadone abuse.
The American review of respiratory disease 1973 Jun;107;1047-51 — 1973 Jun — 1047-51