Philippe Camus, M.D.

Dijon, France

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XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812

Publications

Virzì F, Giacopelli G, Tutone P, Profera L, Giarratano A, Raineri SM, Tomasello S, Accurso G

Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.

Respiratory medicine case reports 2025;56;102238 — 2025 — 102238

Katsenos S, Psathakis K, Nikolopoulou MI, Constantopoulos SH

Mefloquine-induced eosinophilic pneumonia.

Pharmacotherapy 2007 Dec;27;1767-71 — 2007 Dec — 1767-71

Soentjens P, Delanote M, Van Gompel A

Mefloquine-induced pneumonitis.

Journal of travel medicine 2006 May-Jun;13;172-4 — 2006 May-Jun — 172-4

Inoue T, Tanaka E, Sakuramoto M, Minakuchi M, Maeda Y, Maniwa K, Terada K, Goto S, Takeda T, Noma S, Taguchi Y

[Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2005 Feb;43;103-7 — 2005 Feb — 103-7

Davidson AC, Bateman C, Shovlin C, Marrinan M, Burton GH, Cameron IR

Pulmonary toxicity of malaria prophylaxis.

BMJ (Clinical research ed.) 1988 Nov 12;297;1240-1 — 1988 Nov 12 — 1240-1