The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Pulmonary infiltrative eosinophilia and beclomethasone dipropionate.
The New Zealand medical journal 1981 Nov 25;94;394 — 1981 Nov 25 — 394
The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.
Annals of allergy 1977 Aug;39;133-6 — 1977 Aug — 133-6
Inhaled beclomethasone dipropionate in allergic bronchopulmonary aspergillosis. Report to the Research Committee of the British Thoracic Association.
British journal of diseases of the chest 1979 Oct;73;349-56 — 1979 Oct — 349-56