Philippe Camus, M.D.

Dijon, France

Back to drug

The Drug-Induced Respiratory Disease Website

XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

(Fr: PINS aiguë). Acute, generally bilateral and diffuse pneumonitis. More rapid in onset and/or denser, more extensive and severe than pattern Ib. Can be fulminate in the form of diffuse pulmonary interstitial or alveolar opacities and the ARDS picture (see under IIb). BAL is generally lymphocytic and is also indicated to rule out pneumonia due to Pneumocystis, BCG, viruses or other agents particularly in the immunodepressed. Pathology (lung biopsy is not necessary in the majority; before going for the biopsy, please look at PMID 25950989) may disclose dense NSIP, widespread granulomas, or OP depending both on patient and drug. In severe cases pulmonary edema, DAD and/or DAH may develop. Corticosteroid therapy is indicated if patients progress to acute respiratory failure, once an infection has been carefully and resonably ruled out. Transition to pulmonary fibrosis is very uncommon. The boundary between patterns Ia and Ib may be difficult to delineate. See also under IIb

Publications

Sharma S, Patti R, Soni P, Ehrlich S, Kupfer Y

Amiodarone toxicity & the acute respiratory distress syndrome (ARDS).

QJM : monthly journal of the Association of Physicians 2019 Apr 27;; — 2019 Apr 27

Baumann H, Fichtenkamm P, Schneider T, Biscoping J, Henrich M

Rapid onset of amiodarone induced pulmonary toxicity after lung lobe resection - A case report and review of recent literature.

Annals of medicine and surgery (2012) 2017 Sep;21;53-57 — 2017 Sep — 53-57

Yoon U, Marinelli L, Ali S, Huberfeld S, Barrera R, Chang JB

Early Amiodarone-Induced Pulmonary Toxicity after Endovascular Aneurysm Repair: A Case Report.

The International journal of angiology : official publication of the International College of Angiology, Inc 2016 Sep;25;189-92 — 2016 Sep — 189-92

Kumar S, Bangalore S, Kumari R, Grosu H, Jean R

Amiodarone-induced acute respiratory distress syndrome masquerading as acute heart failure.

The Journal of emergency medicine 2012 Nov;43;e311-4 — 2012 Nov — e311-4

Lehmann LH, Weichert W, Schnapauff D, Dietz R, Stockburger M

Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy.

Clinical research in cardiology : official journal of the German Cardiac Society 2008 Dec;97;917-20 — 2008 Dec — 917-20

Rotmensch HH, Liron M, Tupilski M, Laniado S

Possible association of pneumonitis with amiodarone therapy.

American heart journal 1980 Sep;100;412-3 — 1980 Sep — 412-3