The Drug-Induced Respiratory Disease Website

Amiodarone

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Associated with intravenous administration of the drug

Serhan Özcan K, Zengin A, Tatl?su A, Aru?arslan E, Nurkalem Z

Anaphylactic shock associated with intravenous amiodarone.

Journal of cardiology cases 2014 Feb;9;61-62 — 2014 Feb — 61-62

Averin K, Lorts A, Connor C

Anaphylactic shock after amiodarone infusion resulting in haemodynamic collapse requiring a temporary ventricular assist device.

Cardiology in the young 2015 Jan;25;164-6 — 2015 Jan — 164-6

Okuyan H, Altin C, Arihan O

Anaphylaxis during intravenous administration of amiodarone.

Annals of cardiac anaesthesia 2013 Jul-Sep;16;229-30 — 2013 Jul-Sep — 229-30

Kurt ?H, Yalcin F

Anaphylactic shock due to intravenous amiodarone.

The American journal of emergency medicine 2012 Jan;30;265.e1-2 — 2012 Jan — 265.e1-2

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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