The Drug-Induced Respiratory Disease Website
(Fr: SDRA sur critères gazométriques PaO2/FIO2). May overlap with Ia. Mechanical ventilation commonly needed. ECMO required in some instances (PMID 29967877). ARDS definition and grading at PMID 22797452. ARDS (and formerly ALI) are defined on the basis of gas exchange abnormalities. Thus, ARDS is not a well-characterized disease entity and may arise in widely disparate clinical scenarios. Pathologically, ARDS may correspond to DAD, pulmonary edema, acute NSIP-like ILD w/wo granulomas, -eosinophilic pneumonia (AEP), AFOP, amiodarone pulmonary toxicity, DAH, fat or silicone embolism, AIP, radiation injury, pulmonary fibrosis exacerbated by drugs or surgery (see under specific patterns) and drug- or alcohol-induced aspiration pneumonitis (see under XIg). Appropriate tests and BAL help exclude an infection and separate these entities. Some patients respond to intravenous corticosteroid therapy. Review at PMID 1939859. See also under IL 'Diffuse Alveolar Damage', XIg, XVf and under 'Postoperative ARDS'
Publications
Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment.
Mediterranean journal of hematology and infectious diseases 2011;3;e2011048 — 2011 — e2011048
Beer TM, Tangen CM, Nichols CR, Margolin KA, Dreicer R, Stephenson WT, Quinn DI, Raghavan D, Crawford ED
Southwest Oncology Group phase II study of arsenic trioxide in patients with refractory germ cell malignancies.
Cancer 2006 Jun 15;106;2624-9 — 2006 Jun 15 — 2624-9
Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome.
Journal of critical care 2005 Mar;20;111-3 — 2005 Mar — 111-3