Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXXVI.m

DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

DRESS stands for 'Drug Rash, Eosinophilia, Systemic Symptoms or Syndrome'. Includes internal organ involvement (liver, bone marrow, kindney, lung, heart in the form of myocarditis (PMID 21658796)) and occasionally MOF/MODS. Respiratory involvement (in about 15% of the patients), is in the form of cough, dyspnea, wheezing, pleural effusion, pulmonary infiltrates or PIE. See also under eosinophilic pneumonia. A precise definition of the syndrome has been available since 1996 (Bocquet et al.). Earlier cases of 'Drug Hypersensitivity' in the literature likely represent authentic DRESS cases. Review and lists of causal drugs at PMID 21592453, 26354734. Reviews at PMID 23602182, 23602183, 25592341, 30140942. Pulmonary manifestations at PMID 31662996. Causal drugs at PMID 32247873 and 35160164.

the heart in DRESS @ PMID 35160164.

Publications

AlTarrah D, ElSamra Z, Daher W, AlKhas A, Alzafiri L

A cross-sectional study of self-reported dietary supplement use, associated factors, and adverse events among young adults in Kuwait.

Journal of health, population, and nutrition 2024 Aug 08;43;117 — 2024 Aug 08 — 117

Doan KD, Akinsanya A, Kuhar M, Mesa H

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2023 Oct 25;19;92 — 2023 Oct 25 — 92

Ghandourah H, Bhandal S, Brundler MA, Noseworthy M

Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.

BMJ case reports 2016 Jan 29;2016; — 2016 Jan 29

Deshmukh P, Dao H, Parrisbalogun S, Locala JA

Lamotrigine-induced anticonvulsant hypersensitivity syndrome associated with acute respiratory distress syndrome.

Psychosomatics 2011 Sep-Oct;52;495-7 — 2011 Sep-Oct — 495-7

Amante MF, Filippini AV, Cejas N, Lendoire J, Imventarza O, Parisi C

Dress syndrome and fulminant hepatic failure induced by lamotrigine.

Annals of hepatology 2009;8;75-7 — 2009 — 75-7

Chang CC, Shiah IS, Yeh CB, Wang TS, Chang HA

Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.

Progress in neuro-psychopharmacology & biological psychiatry 2006 Jun;30;741-4 — 2006 Jun — 741-4

Knowles SR, Uetrecht J, Shear NH

Idiosyncratic drug reactions: the reactive metabolite syndromes.

Lancet (London, England) 2000 Nov 04;356;1587-91 — 2000 Nov 04 — 1587-91

Schaub N, Bircher AJ

Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.

Allergy 2000 Feb;55;191-3 — 2000 Feb — 191-3