The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
A Case of MDMA-Associated Cerebral and Pulmonary Edema Requiring ECMO.
Case reports in critical care 2017;2017;6417012 — 2017 — 6417012
Isolated non-cardiogenic pulmonary edema - A rare complication of MDMA toxicity.
The American journal of emergency medicine 2017 Sep;35;1385.e3-1385.e6 — 2017 Sep — 1385.e3-1385.e6
MDMA-induced acute pulmonary edema in a patient without other organ dysfunction.
The American journal of emergency medicine 2006 Oct;24;734-6 — 2006 Oct — 734-6
Fatal hyponatremia in a young woman after ecstasy ingestion.
Nature clinical practice. Nephrology 2006 May;2;283-8, quiz 289 — 2006 May — 283-8, quiz 289
Ecstasy--deadly risk even outside rave parties.
Forensic science international 2005 Oct 29;153;227-30 — 2005 Oct 29 — 227-30
Our experiences with fatal ecstasy abuse (two case reports).
Forensic science international 2005 Jan 17;147 Suppl;S77-80 — 2005 Jan 17 — S77-80
Pulmonary oedema caused by "liquid ecstasy" ingestion.
Archives of disease in childhood 2002 Apr;86;302-3 — 2002 Apr — 302-3