The Drug-Induced Respiratory Disease Website

Heparin

Review on heparin-induced thrombocytopenia and its pulmonary complications, a major complication of therapy with heparin, available at PMID 24319250, 16928996

XXXII - Esophageal pathology

XXXII.a

Esophageal hematoma (may cause chest pain and/or tracheal compression)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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