Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

All-transretinoic acid (ATRA)

The PML-RAR inhibitor ATRA or tretinoin can cause the ATRA- or differentiation syndrome with dyspnea, fever, weight gain, hypotension, pulmonary infiltrates and hypoxemia, pulmonary edema, ARDS or DAH w/wo capillaritis. Imaging features at PMID 11804921.

X - Pulmonary edema

X.b

Pulmonary edema, noncardiogenic (NCPE)
X.i

Pulmonary edema/ARDS of the ATRA syndrome
X.j

The differentiation- or ATRA syndrome

XII - Pericardial involvement

XII.b

Pericardial effusion (w/wo tamponade)
XII.n

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XIII - Thrombosis - Embolism

XIII.a

Pulmonary embolism - Venous thrombosis/thrombo-embolism

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)